drugs impairing driving

Significant Odds Ratios for Driver Impairing Drugs

HIC3 DRUG_NAME OR L_OR U_OR P-VALUE A B C D
H2D BARBITURATES 7.50 2.35 23.91 0.00 10 4499 4 13523
Z2F MAST CELL STABILIZERS 3.00 1.05 8.55 0.04 7 4502 7 13520
H6C ANTITUSSIVES,NON-NARCOTIC 2.23 1.30 3.82 0.00 23 4486 31 13496
H3A ANALGESICS,NARCOTICS 2.22 1.98 2.49 0.00 557 3952 806 12721
H7T ANTIPSYCHOTICS,ATYPICAL,DOPAMINE,& SEROTONIN ANTAG 2.20 1.37 3.52 0.00 30 4479 41 13486
H6H SKELETAL MUSCLE RELAXANTS 2.09 1.71 2.55 0.00 167 4342 247 13280
H2F ANTI-ANXIETY DRUGS 2.00 1.72 2.31 0.00 315 4194 490 13037
H4B ANTICONVULSANTS 1.97 1.64 2.38 0.00 189 4320 295 13232
H7E SEROTONIN-2 ANTAGONIST/REUPTAKE INHIBITORS (SARIS) 1.90 1.49 2.44 0.00 105 4404 167 13360
J2A BELLADONNA ALKALOIDS 1.85 1.08 3.19 0.03 21 4488 34 13493
C4G INSULINS 1.80 1.45 2.22 0.00 140 4369 237 13290
A4B HYPOTENSIVES,SYMPATHOLYTIC 1.79 1.17 2.74 0.01 34 4475 57 13470
H7C SEROTONIN-NOREPINEPHRINE REUPTAKE-INHIB (SNRIS) 1.78 1.19 2.66 0.00 38 4471 64 13463
M9P PLATELET AGGREGATION INHIBITORS 1.69 1.17 2.43 0.01 46 4463 83 13444
H6J ANTIEMETIC/ANTIVERTIGO AGENTS 1.63 1.17 2.28 0.00 54 4455 100 13427
H6A ANTIPARKINSONISM DRUGS,OTHER 1.62 0.99 2.66 0.05 25 4484 47 13480
B3K COUGH AND/OR COLD PREPARATIONS 1.62 1.19 2.20 0.00 63 4446 118 13409
H2S SEROTONIN SPECIFIC REUPTAKE INHIBITOR (SSRIS) 1.59 1.40 1.81 0.00 380 4129 741 12786
B3J EXPECTORANTS 1.58 1.28 1.94 0.00 142 4367 275 13252
S2B NSAIDS, CYCLOOXYGENASE INHIBITOR - TYPE 1.58 1.41 1.76 0.00 534 3975 1066 12461
Z2A ANTIHISTAMINES 1.55 1.36 1.78 0.00 349 4160 693 12834
D4K GASTRIC ACID SECRETION REDUCERS 1.55 1.38 1.73 0.00 491 4018 995 12532
C4K HYPOGLYCEMICS, INSULIN-RELEASE STIMULANT TYPE 1.50 1.28 1.76 0.00 238 4271 486 13041
C4L HYPOGLYCEMICS, BIGUANIDE TYPE (NON-SULFONYLUREAS) 1.49 1.23 1.80 0.00 169 4340 345 13182
H2E SEDATIVE-HYPNOTICS,NON-BARBITURATE 1.48 1.16 1.88 0.00 100 4409 206 13321
H2U TRICYCLIC ANTIDEPRESSANTS & REL. NON-SEL. RU-INHIB 1.41 1.15 1.73 0.00 139 4370 300 13227
J5D BETA-ADRENERGIC AGENTS 1.35 1.12 1.64 0.00 157 4352 352 13175
C4N HYPOGLYCEMICS, INSULIN-RESPONSE ENHANCER (N-S) 1.35 1.01 1.80 0.04 68 4441 152 13375
R1M LOOP DIURETICS 1.35 1.10 1.65 0.00 136 4373 306 13221
R1L POTASSIUM SPARING DIURETICS IN COMBINATION 1.33 1.10 1.61 0.00 161 4348 366 13161
A7B VASODILATORS,CORONARY 1.31 1.04 1.66 0.02 103 4406 237 13290
M9L ORAL ANTICOAGULANTS,COUMARIN TYPE 1.31 1.01 1.70 0.04 84 4425 193 13334
P3A THYROID HORMONES 1.29 1.12 1.48 0.00 307 4202 730 12797
A9A CALCIUM CHANNEL BLOCKING AGENTS 1.25 1.10 1.41 0.00 401 4108 985 12542
A4D HYPOTENSIVES, ACE INHIBITORS 1.23 1.11 1.37 0.00 534 3975 1330 12197


Leroy A, Morse MM.APPENDIX VIII. Table 1B Significant Odds Ratios for Driver Impairing Drugs.US Department of Transportation/National Highway Traffic Safety Administration. Exploratory study of the relationship between multiple medications and vehicle crashes: analysis of databases. Washington, DC: U.S.DOT/NHTSA; 2008: Publication DTNH22-02-C-05075. P210 May, 2008.
https://www.nhtsa.gov/sites/nhtsa.dot.gov/files/810858.pdf